Scroll down to see the top ten characters we still can't believe are gone. You might want to grab the tissues.
1 / 0
Derek Shepherd (Patrick Dempsey)
Meredith tragically lost her husband Derek when he was hit by a truck in a road accident. Derek was rushed to a small hospital but unfortunately didn’t receive the life-saving treatment he needed.
Meredith (Ellen Pompeo) then had to make the terrible decision to turn off his life-support machine.
2 / 0
Lexie Grey (Chyler Leigh)
Meredith was united with her long-lost half sister and then had to witness her death. Lexie was killed in the plane crash that injured several other doctors.
Her last scenes where she told Mark she loved him left fans sobbing.
3 / 0
Mark Sloan (Eric Dane)
Dr McSteamy became the second casualty from the plane crash when he succumbed to the injuries he’d sustained in the accident.
Mark slipped in to a coma and was removed from life support after a month by Callie (Sara Rodriguez).
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George (T. R. Knight)
Meredith’s best friend was admitted to hospital as a John Doe. He’d been hit by a bus and horribly disfigured after saving a woman’s life. Meredith and her colleagues only realised it was George when he traced “007” on Meredith’s hand.
5 / 0
Denny Duquette Jr (Jeffrey Dean Morgan)
Izzy (Katherine Heigl) did everything in her power to try and save patient Denny, who she’d fallen in love with. He made it through a heart transplant, but then later died.
Alex (Justin Chambers) carrying a heartbroken Izzy out of the hospital is one of the show’s most memorable scenes.
6 / 0
Reed Adamson (Nora Zehetner)
The surgical intern was killed in the hospital when Gary Clark (Michael O’Neill) came to the hospital to seek vengeance for his wife’s death. He blamed the team of doctors who treated his wife for her death.
Reed was shot dead at point-blank when she wouldn’t tell Gary where to find Derek (Patrick Dempsey).
7 / 0
Charles Percy (Robert Baker)
The intern’s death was one of the most tearful scenes to watch in Grey’s Anatomy. After he was shot in the hospital shooting, Bailey (Chandra Wilson) tried in vain to save his life.
However she couldn’t get Percy to a surgical room and he slowly bled out as Bailey held him in her arms.
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Adele Webber (Loretta Devine)
Richard’s (James Pickens Jr.) wife was diagnosed with Alzheimer’s disease and quickly deteriorated. Adele was admitted to a medical care facility and died off-screen.
It was at Bailey’s (Chandra Wilson) wedding that Richard informed Meredith (Ellen Pompeo) his wife had passed away.
9 / 0
Dylan Young (Kyle Chandler)
Meredith had to operate on a patient who had a bomb inside them. She managed to remove it, and then passed the device to the bomb squad captain Dylan.
Sadly, as he was walking the bomb out of the hospital it exploded and Dylan was killed.
10 / 0
Henry Burton (Scott Foley)
Henry was a frequent patient at the hospital because he had a medical condition. He ended up getting married to doctor Teddy (Kim Raver). Cristina (Sandra Oh) had to operate on Henry when he fell ill and was unaware of the patient’s identity.
Despite her best efforts, Henry died on the operating table.