The Aussie starlet's latest project, Lion, is a story that hits right at home for the mother-of-two adopted kids.
Portraying an adoptive mother in the film, the 49-year-old was able to dig into her own personal experiences.
Bella, 23, and 21-year-old Connor became a part of Nicole's family during her 11-year marriage to Tom Cruise.
Chatting to inTouch, the Aussie starlet addressed the idea of adoptive kids seeking out their biological parents.
“Every family’s experience with this is distinct and private,” she admitted.
“But we live in an ever more transparent world, technologically speaking. Kids are resourceful,” she continued, "and the need to know your origin story is universal.”
Watch Nic talk about her incredible new role in the video player underneath! Article continues...
Lion, based on a true story, is about an Australian couple whose adopted son from India sets out to find the family he was separated from as a child.
The film is already garnering Oscar buzz, with Nicole admitting it resonated with her on a personal level.
"It's about the power of mothers - whether they are biological of adoptive. It's very personal for me," she mused to The Hollywood Reporter.
It's been reported that Nicole, who is also the biological mother to daughters Sunday Rose, eight, and Faith Margaret, five, with husband Keith Urban, has a fractured relationship with her two eldest kids from her first marriage.
Chatting directly to Woman's Day in 2014, Connor insisted there was no bad blood. "I don't care what people say. I know that me and mum are solid. I love her a lot. My family means everything."
Him mum echoed his sentiment, telling Vanity Fair, "I also have a really solid, wonderful family and relationship!”
Check out the trailer to Lion in the player below! Post continues...
While Nic rarely speaks of her family, she did admit she's thankful for her first marriage.
"I got married really fast and really young," she revealed in 2012, "But I don't regret that because it got me Bella and Connor and I did have a fantastic marriage for a long period."
Explaining that she has "unconditional love" for her four kids, Nicole explained to DuJour magazine that she relies on technology to stay in touch with them.
"I have four children, so to stay in touch with them is very important," she said.
"I’m definitely engaged in it but I don’t let it rule my life."
Watch Nicole talk about her love for life in Nashville with Keith and the girls in the player below!