Reports made by TMZ allege that the former NBA great had boarded a plane at Los Angeles International Airport on Monday en route to New York City, but he never made it to his final destination.
Onlookers told the site he was “pounding down” whisky and beer in the Delta first class lounge before the flight.
Check out the shocking moment in the player below! Post continues...
Lamar reportedly vomited on himself, in the aisle of the plane and in one of the aircraft's bathrooms, which lead to his removal from the flight before it had even taken off.
He allegedly then returned minutes later, only to return to the bathroom.
He was then removed for the second and final time, following a reported complaint from a first-class passenger.
TMZ have also revealed a passenger's shocking set of photos from the incident, which claim to show Lamar's vomit on the floor of the plane. "When Lamar Odom vomits on the plane," the caption reads.
Seemingly commenting on the situation, Khloe simply tweeted a sad face emoji.
Many came to the 32-year-old's support, with one user penning: “You’re doing what you can, unfortunately he makes his own choices. Stay strong.”
But Khloe soon came under fire when a critic slammed her for supposedly “running the streets” with other guys, addressing speculation that she is dating rapper Trey Songz, rather than focusing on her former husband.
Watch Khloe address her ex's plane incident in the video underneath... Post continues!
“Stay in your f--king lane, little girl,” she retorted. “You know nothing about anything. You’re a sheep herded by society.”
In February, Khloe admitted that she had no desire to remain married to Lamar despite helping him through his October overdose.
“We're not back together. We're not at all. I love him with every fiber of my being…but we were married and I shared that union with him," she explained on The Talk.
"I didn't want for our divorce to happen, but it happened for many reasons and that doesn't mean I just forget about this person."
It’s undoubtedly been a tumultuous time for Lamar.
With the divorce proceedings back on, on top of moving out his Calabasas home that Khloe provided to help him recover, there's no doubt the 36-year-old is under a lot of stress.
Meanwhile, fresh reports claim the reality star was spotted drinking alone at Los Angeles strip venue, 4Play Gentlemen's Club, before he arrived at the airport on Monday.
"When he was first drinking again, some said he was just getting back to normal – clearly this was just a gateway back to his destructive behaviour," one source told People, who believes that the former basketballer "is an addict and should never have been drinking again."
This week marks nine months since Lamar's hospitalisation after being found unconscious in a Nevada brothel from a drug overdose.