The talk show queen will head to Channel Ten for a very special All Star Family Feud episode.
KAK will captain her fellow television hosts Tony Barber, Glenn Ridge and John Burgess.
The TV hosts team will be playing for their chosen charity Look Good Feel Better, which helps cancer suffers with "appearance-related side-effects caused by cancer treatment."
Playing opposite them is Sandra Sully, team captain for the newsreaders.
Ron Wilson, Natarsha Belling and Stephen Quartermain join the veteran journalist, and they're competing for, the McGrath Foundation and the Unicorn Foundation.
Check out a sneak peek pf Monday’s episode in the video player... Article continues below!
2016 has been exceptionally difficult year for Kerri-Anne following her husband's horrific accident.
The 63-year-old has supported John since his life-changing injury five months ago, which left him partially paralysed.
She has previously said that his progress in recovering from the broken neck he sustained has been “very slow."
But the determined star is currently transforming their Sydney house and garden to make it wheel-chair friendly in preparation for her 75-year-old husband’s homecoming at the end of the year.
She admitted to Private Sydney, "If all goes to plan he should be back in November, with Christmas here ... that would be a true blessing!"