The 46-year-old sat down with British talk show hosts Holly Willoughby and Phillip Schofield in London on Tuesday to discuss his new play The End of Longing, but fans quickly picked up on the actor’s slurred speech and disheveled appearance.
Voicing their concern on Twitter, some users questioned whether the Friends star was "drunk."
"Is Matthew Perry ok? He seemed not to be with it, slurring his words like he was drunk, tired or on meds," one viewer penned.
While another worried fan tweeted: "Matthew Perry seemed half asleep & slurred on @itvthismorning - hope he's ok."
Understandably, the actor who found fame over a decade ago as the lovable Chandler Bing on Friends, has had a very intense couple of months.
He’s currently appearing seven times a week in his self-penned play, which opened on the West End in early February and will finish in May.
Fans were also worried by the actor's unkempt appearance, with many pointing out how exhausted he looked.
In the past Matthew has always been open about his personal battles.
In 1997, three years after the pilot episode of Friends aired, the star was prescribed Vicodin after an accident with a Jet Ski. The actor was already battling a drinking problem at the time, and the added drug addiction sparked a years-long struggle to get clean.
“I couldn’t stop,” he told People in 2013.
“Eventually things got so bad that I couldn’t hide it, and then everybody knew.”
See Matthew talk about his struggles in the player below. Post continues after.
The actor completed his first stint in rehab in 1997 for Vicodin addiction, and his second in February 2001 for addiction to opioids, amphetamines and alcohol.
Now, Matthew is a passionate advocate for others going through the same journey and often speaks candidly about his history with addiction.
In 2013, he received a Champion of Recovery award from the White House for his work with Perry House, a sober-living facility he created out of his former Malibu mansion.
Matthew has since sold the property but told The Hollywood Reporter he plans to relocate the facility to a smaller place in Santa Monica or Studio City.